FGFR4-IN-17
FGFR4-IN-17 (Compound (S) -23) is a piperazinyl diflurindan derivative containing pyridinyl. FGFR4-IN-17 is a FGFR inhibitor with IC50 values of 24.2, 16.1, 78.0, and 68.0 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FGFR4-IN-17 has antitumor activity[1].
Product Specifications
CAS Number
3011805-61-8
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-17.html
Solubility
10 mM in DMSO
Smiles
FC1(C2=CC(NC(C3=CC(C#CC4=CN=CC(OC)=C4)=C(C=C3)F)=O)=CC=C2[C@@H](N5CCN(CC5)C)C1)F
Molecular Formula
C29H27F3N4O2
Molecular Weight
520.55
References & Citations
[1]Ding W, et al. Identification of Piperazinyl-Difluoro-indene Derivatives Containing Pyridyl Groups as Potent FGFR Inhibitors against FGFR Mutant Tumor: Design, Synthesis, and Biological Evaluation. J Med Chem. 2024 Jan 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2412754 100 µL
Phospho-BRCA1 (Ser1189) Rabbit Polyclonal Antibody (PerCP-Cy5.5)
Sign In for Pricing
View Details ![Human RBP4 Matched Antibody Pair Set [ABP-S-03852]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
ABP-S-03852 5 Plates
Human RBP4 Matched Antibody Pair Set [ABP-S-03852]
Sign In for Pricing
View Details 126215 100 µg
EHHADH (Peroxisomal Bifunctional Enzyme, PBE, PBFE, Enoyl-CoA Hydratase/3,2-trans-enoyl-CoA Isomerase, 3-hydroxyacyl-CoA Dehydrogenase, ECHD)
Sign In for Pricing
View Details 
bs-8042R-BF647 100 µL
HIAT1 Polyclonal Antibody, AbBy Fluor™ 647 Conjugated
Sign In for Pricing
View Details