Iminostilbene
Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2) . Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases[1][2].
Product Specifications
CAS Number
256-96-2
UNSPSC
12352005
Hazard Statement
H302, H401, H411
Target
COX; HIF/HIF Prolyl-Hydroxylase; Interleukin Related; NO Synthase; Pyruvate Kinase; STAT; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/iminostilbene.html
Purity
99.34
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C12=CC=CC=C1C=CC3=CC=CC=C3N2
Molecular Formula
C14H11N
Molecular Weight
193.25
Precautions
H302, H401, H411
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2; HIF-1α; iNOS; STAT3
Available Sizes
Frequently Asked Questions
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