NMS-873
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM.
Product Specifications
CAS Number
1418013-75-8
UNSPSC
12352005
Hazard Statement
H302
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NMS-873.html
Purity
99.92
Solubility
DMSO : 20.5 mg/mL (ultrasonic; warming)
Smiles
CC(C=C(OCC1=NN=C(SC2CCCC2)N1C3=CC=CN=C3)C=C4)=C4C5=CC=C(S(=O)(C)=O)C=C5
Molecular Formula
C27H28N4O3S2
Molecular Weight
520.67
Precautions
H302
References & Citations
[1]Paola Magnaghi, et al. Covalent and allosteric inhibitors of the ATPATP ase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Jul 28. doi: 10.1038/nchembio.1313.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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