PROTAC SMARCA2/4-degrader-5

PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 SMARCA4 in MV411 with DC50 of 100-500 nM. (Pink: Ligand for target protein (HY-159545) ; Black: Linker (HY-159557) ; Blue: Ligand for E3 ligase (S, R, S) -AHPC (HY-125845) ) [1]

Product Specifications

CAS Number

[2568277-84-7]

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-smarca2-4-degrader-5.html

Smiles

NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6=CC=C(C=C6)C[C@@H]7CC[C@H](CC7)C(N[C@@H](C(C)(C)C)C(N8[C@@H](C[C@H](C8)O)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O)C=N5)C(CC4)C3