PROTAC SMARCA2/4-degrader-5
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 SMARCA4 in MV411 with DC50 of 100-500 nM. (Pink: Ligand for target protein (HY-159545) ; Black: Linker (HY-159557) ; Blue: Ligand for E3 ligase (S, R, S) -AHPC (HY-125845) ) [1]
Product Specifications
CAS Number
[2568277-84-7]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-4-degrader-5.html
Smiles
Molecular Formula
C56H65N11O5S
Molecular Weight
1004.25
References & Citations
[1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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