pan-KRAS-IN-13
Product Specifications
UNSPSC Description
pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC50s of 2.75 nM and 2.89 nM for G12D and G12V, respectively[1]
Target Antigen
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-13.html
Solubility
10 mM in DMSO
Smiles
FC1=C(C#C)C2=C(C3=NC(OCC4)=C(C(N5[C@@H]4CNCC5)=NC(OC[C@]6(C[C@@H](F)C7)N7CCC6)=N8)C8=C3F)C=C(O)C=C2C=C1
Molecular Weight
616.63
References & Citations
[1]Ildong Pharmaceutical Co., Ltd. Novel tetraheterocycle compound. World Intellectual Property Organization, WO2024063578 A1 2024-03-28
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162446/pan-KRAS-IN-13-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162446/
Clinical Information
No Development Reported
CAS Number
3033637-76-9
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