Pan-KRAS-IN-13
Pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC50s of 2.75 nM and 2.89 nM for G12D and G12V, respectively[1]
Product Specifications
CAS Number
[3033637-76-9]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-13.html
Solubility
10 mM in DMSO
Smiles
FC1=C(C#C)C2=C(C3=NC(OCC4)=C(C(N5[C@@H]4CNCC5)=NC(OC[C@]6(C[C@@H](F)C7)N7CCC6)=N8)C8=C3F)C=C(O)C=C2C=C1
Molecular Formula
C33H31F3N6O3
Molecular Weight
616.63
References & Citations
[1]Ildong Pharmaceutical Co., Ltd. Novel tetraheterocycle compound. World Intellectual Property Organization, WO2024063578 A1 2024-03-28
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Curated Selection
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