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Pan-KRAS-IN-13

Pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC50s of 2.75 nM and 2.89 nM for G12D and G12V, respectively[1]

Product Specifications

CAS Number

[3033637-76-9]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pan-kras-in-13.html

Solubility

10 mM in DMSO

Smiles

FC1=C(C#C)C2=C(C3=NC(OCC4)=C(C(N5[C@@H]4CNCC5)=NC(OC[C@]6(C[C@@H](F)C7)N7CCC6)=N8)C8=C3F)C=C(O)C=C2C=C1

Molecular Formula

C33H31F3N6O3

Molecular Weight

616.63

References & Citations

[1]Ildong Pharmaceutical Co., Ltd. Novel tetraheterocycle compound. World Intellectual Property Organization, WO2024063578 A1 2024-03-28

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

Curated Selection

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