Melanoma gp100 Recombinant Rabbit Monoclonal Antibody [JE42-47]
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
PMEL, D12S53E, PMEL17, SILV
Swiss Prot
P40967 Human, Q60696 Mouse
Cellular Locus
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide within Human Melanoma gp100 aa 617-661 / 661.
Isotype
IgG
Clone
JE42-47
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
SK-MEL-28 cell lysates, human melanoma tissue, mouse testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 70 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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