Melanoma gp100 Recombinant Rabbit Monoclonal Antibody [JE42-47]
Selected Variant
HA721719
Size: 100 µL
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
PMEL, D12S53E, PMEL17, SILV
Swiss Prot
P40967 Human, Q60696 Mouse
Cellular Locus
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within Human Melanoma gp100 aa 617-661 / 661.
Isotype
IgG
Clone
JE42-47
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
SK-MEL-28 cell lysates, human melanoma tissue, mouse testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 70 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Price
Frequently Asked Questions
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