Sulfamethoxazole-d4

Sulfamethoxazole-d4 (Ro 4-2130-d4) is a deuterium labeled Sulfamethoxazole (HY-B0322) . Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis[1][2][3].

Product Specifications

CAS Number

[1020719-86-1]

Product Name Alternative

Ro 4-2130-d4

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335

Target

Antibiotic; Bacterial; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Purity

99.32

Solubility

DMSO : 50mg/mL (ultrasonic)

Smiles

O=S(C1=C([2H])C([2H])=C(N)C([2H])=C1[2H])(NC2=NOC(C)=C2)=O

Molecular Formula

C10H7D4N3O3S

Molecular Weight

257.30

Precautions

H315, H317, H319, H335

References & Citations

[1]Zambuzzi-Carvalho et al. Transcriptional profile of the human pathogenic fungus Paracoccidioides lutzii in response to sulfamethoxazole. Med Mycol. 2015;53 (5) :477-492. |[2]Choonara BF, et al. A menthol-based solid dispersion technique for enhanced solubility and dissolution of sulfamethoxazole from an oral tablet matrix. AAPS PharmSciTech. 2015 Aug;16 (4) :771-86.|[3]Ogata H, et al. Dose Dependent Effect of Sulfamethoxazole on Inhibiting KATP Channel of Mouse Pancreatic β Cell. Dose Response. 2023 Sep 28;21 (3) :15593258231203611.