Spadin
Spadin, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with IC50 value of 10 nM. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin can be used for antidepressant research[1][2].
Product Specifications
CAS Number
1270083-24-3
UNSPSC
12352209
Target
5-HT Receptor; Potassium Channel
Type
Peptides
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/spadin.html
Purity
99.84
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(N[C@@H](C)C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(NCC(N5[C@@H](CCC5)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC8=CC=C(C=C8)O)N
Molecular Formula
C96H142N26O22
Molecular Weight
2012.34
References & Citations
[1]Borsotto M, et, al. Targeting two-pore domain K (+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br J Pharmacol. 2015 Feb;172 (3) :771-84. |[2]Mazella J, et, al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8 (4) :e1000355.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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