WAY-361789

WAY-361789 (SEN15924) is an orally active agonist for α7 nicotinic acetylcholine receptor (α7 nAChR) with an EC50 of 0.18 μM. WAY-361789 improves the cognitive function, exhibits potential in ameliorating Alzheimer’s Disease and schizophrenia[1].

Product Specifications

CAS Number

[1040718-40-8]

Product Name Alternative

SEN15924

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/way-361789.html

Smiles

O=C(NC1=NNC(C2=CC=C(OC)C=C2)=C1)CCCCN3CCN(C(C)=O)CCC3

Molecular Formula

C22H31N5O3

Molecular Weight

413.51

References & Citations

[1]Zanaletti R, et al. Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5- (4-acetyl[1,4]diazepan-1-yl) pentanoic acid [5- (4-methoxyphenyl) -1H-pyrazol-3-yl] amide (SEN15924, WAY-361789) . J Med Chem. 2012 May 24;55 (10) :4806-23.