(2R,4R) -1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1

Product Specifications

CAS Number

[114676-69-6]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-boc-cis-4-hydroxy-d-proline-methyl-ester.html

Purity

99.96

Solubility

10 mM in DMSO

Smiles

CC(C)(C)OC(N1[C@H](C[C@H](C1)O)C(OC)=O)=O

Molecular Formula

C11H19NO5

Molecular Weight

245.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.