Enadoline
Enadoline (CI-977) is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (Ki=1.25 nM) . Antinociceptive effects[1][2].
Product Specifications
CAS Number
124378-77-4
Product Name Alternative
CI-977
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/enadoline.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1=C2C(OC=C2)=CC=C1)N([C@@H]3[C@](N4CCCC4)([H])C[C@]5(CCCO5)CC3)C
Molecular Formula
C24H32N2O3
Molecular Weight
396.52
References & Citations
[1]Field MJ, et al. Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain. 1999;80 (1-2) :383-389. |[2]Vanderah TW, Largent-Milnes T, Lai J, et al. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. Eur J Pharmacol. 2008;583 (1) :62-72.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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