S6821
S6821 is a TAS2R8 antagonist with IC50 value of 0.035 μM. S6821 is not found to be mutagenic or disruptive in vitro, nor is it found to induce micronucleus in bone marrow polychromatic erythrocytes in vivo[1].
Product Specifications
CAS Number
1119831-25-2
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Taste Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/s6821.html
Purity
96.60
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CN(CC3=C(C)ON=C3C)N=C2)C(CN1CC4=CC(O)=CC=C4)=O
Molecular Formula
C19H19N5O4
Molecular Weight
381.39
Precautions
H302, H312, H332
References & Citations
[1]Karanewsky DS, et al. Toxicological evaluation of two novel bitter modifying flavour compounds: 3- (1- ((3,5-dimethylisoxazol-4-yl) methyl) -1H-pyrazol-4-yl) -1- (3-hydroxybenzyl) imidazolidine-2,4-dione and 3- (1- ((3,5-dimethylisoxazol-4-yl) methyl) -1H-pyrazol-4-yl) -1- (3-hydroxybenzyl) -5,5-dimethylimidazolidine-2,4-dione. Toxicol Rep. 2016 Feb 28;3:310-327.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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