S6821

S6821 is a TAS2R8 antagonist with IC50 value of 0.035 μM. S6821 is not found to be mutagenic or disruptive in vitro, nor is it found to induce micronucleus in bone marrow polychromatic erythrocytes in vivo[1].

Product Specifications

CAS Number

[1119831-25-2]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Taste Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/s6821.html

Purity

96.60

Solubility

10 mM in DMSO

Smiles

O=C1N(C2=CN(CC3=C(C)ON=C3C)N=C2)C(CN1CC4=CC(O)=CC=C4)=O

Molecular Formula

C19H19N5O4

Molecular Weight

381.39

Precautions

H302, H312, H332

References & Citations

[1]Karanewsky DS, et al. Toxicological evaluation of two novel bitter modifying flavour compounds: 3- (1- ((3,5-dimethylisoxazol-4-yl) methyl) -1H-pyrazol-4-yl) -1- (3-hydroxybenzyl) imidazolidine-2,4-dione and 3- (1- ((3,5-dimethylisoxazol-4-yl) methyl) -1H-pyrazol-4-yl) -1- (3-hydroxybenzyl) -5,5-dimethylimidazolidine-2,4-dione. Toxicol Rep. 2016 Feb 28;3:310-327.