TRV055

TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs) . TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses[1][2].

Product Specifications

CAS Number

[25849-90-5]

Product Name Alternative

TRV120055

UNSPSC

12352209

Target

Angiotensin Receptor; ERK

Type

Peptides

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trv055.html

Purity

99.47

Solubility

H2O : 33.33 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)

Smiles

O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](C(C)C)NC(CN)=O)=O)CC(C=C3)=CC=C3O)=O)=O)CC4=CN=CN4

Molecular Formula

C42H57N9O9

Molecular Weight

831.96

References & Citations

[1]Dallagnol JCC, et al. G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts. ACS Chem Biol. 2023 Sep 15;18 (9) :2050-2062. |[2]Parichatikanond W, et al. Gαq protein-biased ligand of angiotensin II type 1 receptor mediates myofibroblast differentiation through TGF-β1/ERK axis in human cardiac fibroblasts. Eur J Pharmacol. 2023 Jul 15;951:175780.