(+) -Plakevulin A

(+) -Plakevulin A (Plakevulin A) is an oxylipin and can be isolated from an Okinawan sponge Plakortis sp. (+) -Plakevulin A inhibits the enzymatic activity of DNA polymerases α and δ. (+) -Plakevulin A induces apoptosis and shows anticancer activity[1].

Product Specifications

CAS Number

[518035-27-3]

UNSPSC

12352211

Target

Apoptosis; DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/plus-plakevulin-a.html

Smiles

COC([C@H]1[C@@](O)(C=C[C@@H]1O)CCCCCCCCCCCCCCCC)=O

Molecular Formula

C23H42O4

Molecular Weight

382.58

References & Citations

[1]Kabasawa M, et al . Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells. Bioorg Med Chem Lett. 2024 Sep 15;110:129886.