ES 6864
ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets[1].
Product Specifications
CAS Number
116326-39-7
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/es-6864.html
Smiles
O=C(N1CCOCC1)C[C@H](C(N[C@H](C(N[C@@H](CC2CCCCC2)[C@@H](O)CC(NCCN3CCOCC3)=O)=O)CC4=CSC=N4)=O)CC5=CC=CC6=C5C=CC=C6
Molecular Formula
C42H58N6O7S
Molecular Weight
791.01
References & Citations
[1]Hiwada K, et al., A highly potent and long-acting oral inhibitor of human renin. Hypertension. 1988 Jun;11 (6 Pt 2) :708-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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