Adenosine monophosphate-d12 (dilithium)

Adenosine monophosphate-d12 (AMP-d12) dilithium is deuterium labeled Adenosine monophosphate (HY-A0181) . Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction[1][2][3].

Product Specifications

Product Name Alternative

AMP-d12 (dilithium)

UNSPSC

12352005

Target

Adenosine Receptor; Endogenous Metabolite; HSV; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Concentration

100 mM in 26.94 μL Tris HCl/D2O buffer pH=7.5

Purity

95.70

Solubility

10 mM in DMSO

Smiles

O=P(O[Li])(O[Li])OC([2H])([2H])[C@@]1([2H])O[C@](N2C3=NC([2H])=NC(N([2H])[2H])=C3N=C2[2H])([2H])[C@](O[2H])([2H])[C@]1([2H])O[2H]

Molecular Formula

C10D12Li2N5O7P

Molecular Weight

371.16

References & Citations

[1]Rittiner JE, et al. AMP is an adenosine A1 receptor agonist. J Biol Chem. 2012 Feb 17;287 (8) :5301-9. |[2]Zhan Y, et al. Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice. Cell Death Dis. 2014 Jan 9;5:e985. |[3]Ayisi NK, et al. Comparison of the antiviral effects of 5-methoxymethyldeoxyuridine-5'-monophosphate with adenine arabinoside-5'-monophosphate. Antiviral Res. 1983 Sep;3 (3) :161-74.