GSK3368715
GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8) ) . GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity[1].
Product Specifications
CAS Number
[1629013-22-4]
Product Name Alternative
EPZ019997
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk3368715.html
Concentration
10mM
Purity
99.41
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CNCCN(CC1=CNN=C1C2CCC(COCC)(COCC)CC2)C
Molecular Formula
C20H38N4O2
Molecular Weight
366.54
Precautions
H315, H319, H320
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PRMT1; PRMT3; PRMT4; PRMT6; PRMT8
Citation 01
Available Sizes
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