Pogostone

Pogostone is isolated from patchouli oil with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml [2]. Pogostone induces cell apoptosis and autophagy[2].

Product Specifications

CAS Number

[23800-56-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Bacterial

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Infection; Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/pogostone.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(C(CCC(C)C)=O)=C(O)C=C(C)O1

Molecular Formula

C12H16O4

Molecular Weight

224.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Peng F, et al. In vitro and in vivo antibacterial activity of Pogostone.Chin Med J (Engl) . 2014;127 (23) :4001-5.|[2]Cao ZX, et al. Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells.J Ethnopharmacol. 2017 Apr 18;202:20-27.