2G-HaloAUTAC
Product Specifications
UNSPSC Description
2G-HaloAUTAC (Compound tt44) is a second-generation autophagy-targeting chimera (2G-HaloAUTAC) that improves the activity of AUTACs by replacing the L-Cysteine (L-Cys) linker with other structures. 2G-HaloAUTAC exhibits degradation activity against EGFP-HaloTag protein through an autophagic mechanism[1].
Target Antigen
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2g-haloautac.html
Smiles
O=C1N=C(NC2=C1N=C(N2CC3=CC=C(C=C3)F)C4=CN(CCOCCOCCOCCOCCOCCCCCCCl)N=C4)N
Molecular Weight
664.17
References & Citations
[1]Takahashi D, et al., Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem. 2023 Sep 14;66(17):12342-12372.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160902/2G-HaloAUTAC-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160902/
Clinical Information
No Development Reported
CAS Number
2241668-58-4
Curated Selection
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