2G-HaloAUTAC

2G-HaloAUTAC (Compound tt44) is a second-generation autophagy-targeting chimera (2G-HaloAUTAC) that improves the activity of AUTACs by replacing the L-Cysteine (L-Cys) linker with other structures. 2G-HaloAUTAC exhibits degradation activity against EGFP-HaloTag protein through an autophagic mechanism[1].

Product Specifications

CAS Number

[2241668-58-4]

UNSPSC

12352005

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2g-haloautac.html

Smiles

O=C1N=C(NC2=C1N=C(N2CC3=CC=C(C=C3)F)C4=CN(CCOCCOCCOCCOCCOCCCCCCCl)N=C4)N

Molecular Formula

C31H43ClFN7O6

Molecular Weight

664.17

References & Citations

[1]Takahashi D, et al., Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem. 2023 Sep 14;66 (17) :12342-12372.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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