AZ12672857
Product Specifications
UNSPSC Description
AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM)[1].
Target Antigen
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ephb4-kinase-inhibitor-1.html
Smiles
CN(C1=CC=CC2=C1C=NN2)C3=NC(NC4=CC(N5CCOCC5)=CC(N6CCOCC6)=C4)=NC=C3
Molecular Weight
486.57
References & Citations
[1]Bardelle C, et al. Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors. Bioorg Med Chem Lett. 2010;20(21):6242-6245.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-136895/AZ12672857-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-136895/AZ12672857-SDS-MedChemExpress.pdf
CAS Number
945396-55-4
Available Sizes
Curated Selection
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