Dicloxacillin (Sodium hydrate)

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus[1][2][3].

Product Specifications

CAS Number

[13412-64-1]

Product Name Alternative

Dicloxacillin sodium salt monohydrate

UNSPSC

12352005

Hazard Statement

H315, H319, H334, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Dicloxacillin-Sodium-hydrate.html

Concentration

10mM

Purity

98.94

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(O[Na])[C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=O)N1C2=O.O

Molecular Formula

C19H18Cl2N3NaO6S

Molecular Weight

510.32

Precautions

H315, H319, H334, H335

References & Citations

[1]Jusko WJ, et al. Enhanced renal excretion of dicloxacillin in patients with cystic fibrosis. Pediatrics. 1975 Dec;56 (6) :1038-44.|[2]Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin Microbiol Antimicrob. 2006 Oct 12;5:25.|[3]Anne Sandberg, et al. Intra- and extracellular activities of dicloxacillin against Staphylococcus aureus in vivo and in vitro. Antimicrob Agents Chemother. 2010 Jun;54 (6) :2391-400.|[4]John Chu, et al. Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nat Chem Biol. 2016 Dec;12 (12) :1004-1006.