Elgemtumab

Elgemtumab (LJM716) is a fully human IgG monoclonal antibody. Elgemtumab can specifically bind to HER3, block ligand-dependent and independent HER3 signal transduction and cell proliferation, and has good anti-tumor potential[1].

Product Specifications

CAS Number

[1512559-37-3]

Product Name Alternative

LJM716

UNSPSC

12352203

Target

EGFR

Type

Inhibitory Antibodies

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/elgemtumab.html

Purity

99.00

Solubility

10 mM in DMSO

Smiles

[Elgemtumab]

Molecular Weight

(143.977 kDa)

References & Citations

[1]Andrew P Garner, et al. An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer Res. 2013 Oct 1;73 (19) :6024-35.