TAK-020

TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate.

Product Specifications

CAS Number

[1627603-21-7]

UNSPSC

12352005

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tak-020.html

Purity

99.93

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1NNC(C2=CC3=C(C(O[C@@H]4CN(C(C=C)=O)CC4)=N2)C=CC=C3)=N1

Molecular Formula

C18H17N5O3

Molecular Weight

351.36

References & Citations

[1]Sabat M, et al. Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S) -5- (1- ((1-Acryloylpyrrolidin-3-yl) oxy) isoquinolin-3-yl) -2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design. J Med Chem. 2021 Sep 9;64 (17) :12893-12902.