Eprinomectin

Eprinomectin (MK-397) is a type of avermectin. Eprinomectin, as a broad-spectrum fungicide, has insecticidal, insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity[1][2][3].

Product Specifications

CAS Number

[123997-26-2]

Product Name Alternative

MK-397

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Apoptosis; Autophagy; Bacterial; Parasite; Reactive Oxygen Species (ROS) ; β-catenin

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Eprinomectin.html

Concentration

10mM

Purity

98.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C[C@H]1[C@@H](NC(C)=O)[C@@H](OC)C[C@H](O[C@@H]2[C@H](C)O[C@@H](O[C@@H](/C(C)=C/C[C@@H](C3)OC4(O[C@@H]([C@@H](CC)C)[C@H](C)C=C4)C[C@H]3OC5=O)[C@@H](/C=C/C=C6CO[C@@H]7[C@@]\6(O)[C@H]5C=C(C)[C@H]7O)C)C[C@@H]2OC)O1

Molecular Formula

C50H75NO14

Molecular Weight

914.13

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Shoop WL, et al. Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. Int J Parasitol. 1996 Nov;26 (11) :1237-42.|[2]Samy A, et al. Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells by targeting the β-catenin signaling pathway. J Cancer Res Clin Oncol. 2023 Sep;149 (11) :9085-9104.|[3]do Nascimento CG, et al. Injectable eprinomectin for cattle: Tick efficacy and pharmacokinetics. J Vet Pharmacol Ther. 2020 Mar;43 (2) :171-178.