Pyridoclax

Pyridoclax is a potential Mcl-1 inhibitor.

Product Specifications

CAS Number

[1651890-44-6]

Product Name Alternative

MR-29072

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Pyridoclax.html

Purity

99.95

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

CC1=CC(C2=NC=C(C3=CC=CN=C3)C=C2/C=C/C4=CC=CC=C4)=CN=C1C5=CC=CN=C5

Molecular Formula

C29H22N4

Molecular Weight

426.51

References & Citations

[1]Gloaguen C, et al. First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. J Med Chem. 2015 Feb 26;58 (4) :1644-68.|[2]Groo AC, et al. Comparison of 2 strategies to enhance Pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis. Eur J Pharm Sci. 2017 Jan 15;97:218-226.