Sp-cAMPS (sodium salt)

Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC50 of 40 μM[1][2][3].

Product Specifications

CAS Number

[142439-95-0]

UNSPSC

12352005

Target

Phosphodiesterase (PDE) ; PKA

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sp-camps-sodium-salt.html

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 86.67 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@](OC2)([S])=O)N3C4=C(C(N)=NC=N4)N=C3.[Na+]

Molecular Formula

C10H11N5NaO5PS

Molecular Weight

367.25

References & Citations

[1]Su H Hung, et al. A new nonhydrolyzable reactive cAMP analog, (Sp) -adenosine-3',5'-cyclic-S- (4-bromo-2,3-dioxobutyl) monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. Bioorg Chem. 2002 Feb;30 (1) :16-31.|[2]L Y Wang, et al. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science. 1991 Sep 6;253 (5024) :1132-5.|[3]Ronald Jäger, et al. Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem. 2012 Jan 6;287 (2) :1210-9.|[4]P A Connelly, et al. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp) -cAMPS and (Rp) -cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. J Biol Chem. 1987 Mar 25;262 (9) :4324-32.|[5]G Dominguez, et al. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221 (2) :865-77.