Tyrphostin 8
Product Specifications
UNSPSC Description
Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM)[1][2][3].
Target Antigen
EGFR; Phosphatase; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;JAK/STAT Signaling;MAPK/ERK Pathway;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tyrphostin-8.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C1=C(C=CC(=C1)O)C=C(C#N)C#N
Molecular Weight
170.17
References & Citations
[1]Soltoff SP. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8.|[2]Xia CQ, et, al. Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats. Pharm Res. 2001 Feb;18(2):191-5.|[3]Martin BL. Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors. Biochem Pharmacol. 1998 Aug 15;56(4):483-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W174279/Tyrphostin-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W174279/Tyrphostin-8-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3785-90-8
Available Sizes
Curated Selection
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