Tyrphostin 8

Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM) [1][2][3].

Product Specifications

CAS Number

[3785-90-8]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

EGFR; Phosphatase; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tyrphostin-8.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C1=C(C=CC(=C1)O)C=C(C#N)C#N

Molecular Formula

C10H6N2O

Molecular Weight

170.17

Precautions

H301, H315, H319, H335

References & Citations

[1]Soltoff SP. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279 (12) :10910-8.|[2]Xia CQ, et, al. Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats. Pharm Res. 2001 Feb;18 (2) :191-5.|[3]Martin BL. Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors. Biochem Pharmacol. 1998 Aug 15;56 (4) :483-8.