Antitumor agent-152
Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of 3H-dC in L1210 leukemia cells with an IC50 value of 1.12 μM[1].
Product Specifications
CAS Number
[1209784-87-1]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-152.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(SCC2=CSC(C3=CC=C(OCC)C(OC)=C3)=N2)=NC(N)=C1
Molecular Formula
C17H19N5O2S2
Molecular Weight
389.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Murphy JM, et al. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013;56 (17) :6696-6708.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1162329-01 0.02 mg (E-Coli)
Recombinant Salmonella paratyphi A Ribosome maturation factor RimP (rimP)
Ask
View Details MBS1162329-02 0.1 mg (E-Coli)
Recombinant Salmonella paratyphi A Ribosome maturation factor RimP (rimP)
Ask
View Details MBS1162329-03 0.02 mg (Yeast)
Recombinant Salmonella paratyphi A Ribosome maturation factor RimP (rimP)
Ask
View Details MBS1162329-04 0.1 mg (Yeast)
Recombinant Salmonella paratyphi A Ribosome maturation factor RimP (rimP)
Ask
View Details 
MBS1162329-05 0.02 mg (Baculovirus)
Recombinant Salmonella paratyphi A Ribosome maturation factor RimP (rimP)
Ask
View Details