ND-336

ND-336 is a selective inhibitor of matrix metalloproteinase (MMP) -2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound[1][2].

Product Specifications

CAS Number

[1807453-83-3]

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nd-336.html

Purity

97.16

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

NCC1=CC=C(OC2=CC=C(C=C2)S(CC3SC3)(=O)=O)C=C1.Cl

Molecular Formula

C16H18ClNO3S2

Molecular Weight

371.90

References & Citations

[1]Gao M, et al. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proc Natl Acad Sci U S A. 2015;112 (49) :15226-15231.|[2]Nguyen TT, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. J Med Chem. 2018;61 (19) :8825-8837.