MS049

MS049, a chemical probe, is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells[1].

Product Specifications

CAS Number

1502816-23-0

UNSPSC

12352005

Hazard Statement

H301

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MS049.html

Purity

98.0

Solubility

DMSO : ≥ 31 mg/mL|H2O : ≥ 100 mg/mL

Smiles

CNCCN1CCC(OCC2=CC=CC=C2)CC1

Molecular Formula

C15H24N2O

Molecular Weight

248.36

Precautions

H301

References & Citations

[1]Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Sep 15.