SHP2-IN-28

SHP2-IN-28 (Compound 7188-0011) is an inhibitor of SHP2 (IC50=54.31 μM) . SHP2-IN-28 exerts its inhibitory effect by binding to the variable site of SHP2 with high selectivity[1].

Product Specifications

UNSPSC

12352005

Target

SHP2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-in-28.html

Solubility

10 mM in DMSO

Smiles

O=C(/C(C1=CC=CC=C1)=N/O)NCC2CCNCC2

Molecular Formula

C14H19N3O2

Molecular Weight

261.32

References & Citations

[1]Yuan Z et al. Discovery of a novel SHP2 allosteric inhibitor using virtual screening, FMO calculation, and molecular dynamic simulation. J Mol Model. 2024 Apr 13;30 (5) :131.