CHMFL-FLT3-122
CHMFL-FLT3-122 is a potent, selective and orally active FLT3 kinase with an IC50 of 40 nM. CHMFL-FLT3-122 shows selectivity for FLT3 over BTK (IC50 of 421 nM) and c-KIT (IC50 of 559 nM) kinases. CHMFL-FLT3-122 induces apoptosis by arresting the cell cycle into the G0/G1 phase[1].
Product Specifications
CAS Number
[1839150-56-9]
UNSPSC
12352005
Target
Apoptosis; FLT3
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chmfl-flt3-122.html
Purity
98.47
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC1=C2C(N([C@H]3CN(CCC3)C(CN(C)C)=O)N=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1
Molecular Formula
C26H29N7O2
Molecular Weight
471.55
References & Citations
[1]Xixiang Li, et al. Discovery of (R) -1- (3- (4-Amino-3- (4-phenoxyphenyl) -1H-pyrazolo[3,4-d]pyrimidin-1-yl) piperidin-1-yl) -2- (dimethylamino) ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia. J Med Chem. 2015 Dec 24;58 (24) :9625-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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