THPP-1

THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species[1].

Product Specifications

CAS Number

[1257051-63-0]

Product Name Alternative

Faropenem medoxil,1-hydroxycholecalciferol-d7; 1.alpha.-Hydroxyvitamin D3-d7

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/thpp-1.html

Purity

98.75

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=CC=CN2C=N1)N3CCC4=NC(C5=CC=C(N=C5)Cl)=NC(OCCOC)=C4C3

Molecular Formula

C23H21ClN6O3

Molecular Weight

464.90

References & Citations

[1]Smith SM, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey. Neuropharmacology. 2013 Jan;64:215-23.|[2]Vardigan JD, et al. Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity. Psychopharmacology (Berl) . 2016 Jul;233 (13) :2441-50.