Exatecan-d3 (mesylate)
Exatecan-d3 (DX8951f-d3) mesylate is deuterium-labeled Exatecan mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL[1].
Product Specifications
Product Name Alternative
DX8951f-d3 (mesylate)
UNSPSC
12352005
Target
ADC Payload; Isotope-Labeled Compounds; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(C)(O)=O.O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C([2H])([2H])[2H])=C(F)C=C6N=C4C3=C2)=O
Molecular Formula
C25H23D3FN3O7S
Molecular Weight
534.57
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Smith K A, et al. Soil and environmental analysis[M]. Marcel Dekker Incorporated, 2000.|[3]Fan T W M, et al. Stable isotope-resolved metabolomics and applications for drug development[J]. Pharmacology & therapeutics, 2012, 133 (3) : 366-391.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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