Amifostine thiol

Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639) . Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3].

Product Specifications

CAS Number

[31098-42-7]

Product Name Alternative

WR-1065

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amifostine-thiol.html

Purity

95.0

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

NCCCNCCS

Molecular Formula

C5H14N2S

Molecular Weight

134.24

Precautions

H302, H312, H332

References & Citations

[1]Jaroslaw Dziegielewski, et al. WR-1065, the Active Metabolite of Amifostine, Mitigates Radiation-Induced Delayed Genomic Instability. Free Radic Biol Med. 2008 Dec 15; 45 (12) : 1674-1681.|[2]Olivier Pluquet, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278 (14) :11879-87. J Biol Chem. 2003 Apr 4;278 (14) :11879-87.|[3]J. S. Murley, et al. WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997 Jun; 30 (6) : 283-294.