Hexokinase from Saccharomyces cerevisiae

<strong>Hexokinase from Saccharomyces cerevisiae</strong>_x000D_ <strong>Catalog number:</strong> B2010460_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1500 units_x000D_ <strong>Molecular Weight or Concentration:</strong> 110 kDa (dimer)_x000D_ <strong>Supplied as:</strong> Lyophilized powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure and high specific activity (‚â•350 units/mg protein) Hexokinase from Saccharomyces cerevisiae._x000D_ <strong>Storage:</strong> 2-8¬∞C_x000D_ <strong>Keywords:</strong> ATP:D-Hexose-6-phosphotransferase, Hexokinase from yeast_x000D_ <strong>Grade:</strong> Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Yin X, Choudhury M, Kang JH, Schaefbauer KJ, Jung MY, Andrianifahanana M,_x000D_ Hernandez DM, Leof EB. Hexokinase 2 couples glycolysis with the profibrotic_x000D_ actions of TGF-Œ≤. Sci Signal. 2019 Dec 17;12(612):eaax4067._x000D_ _x000D_ 2: Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso_x000D_ M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N._x000D_ Hexokinase_2 is required for tumor initiation and maintenance and its systemic_x000D_ deletion is therapeutic in mouse models of cancer. Cancer Cell. 2013 Aug_x000D_ 12;24(2):213-228._x000D_ _x000D_ 3: Ciscato F, Filadi R, Masgras I, Pizzi M, Marin O, Damiano N, Pizzo P, Gori A,_x000D_ Frezzato F, Chiara F, Trentin L, Bernardi P, Rasola A. Hexokinase 2 displacement_x000D_ from mitochondria-associated membranes prompts Ca²⁺ -dependent death_x000D_ of cancer cells. EMBO Rep. 2020 Jul 3;21(7):e49117._x000D_ _x000D_ 4: Nawaz MH, Ferreira JC, Nedyalkova L, Zhu H, Carrasco-L√≥pez C, Kirmizialtin S,_x000D_ Rabeh WM. The catalytic inactivation of the N-half of human hexokinase 2 and_x000D_ structural and biochemical characterization of its mitochondrial conformation._x000D_ Biosci Rep. 2018 Feb 21;38(1):BSR20171666._x000D_ _x000D_ 5: Garcia SN, Guedes RC, Marques MM. Unlocking the Potential of HK2 in Cancer_x000D_ Metabolism and Therapeutics. Curr Med Chem. 2019;26(41):7285-7322._x000D_ _x000D_ 6: Sun J, Zhu F, Chen H, Yao M, Zhu G, Zhang Y, Wang Q, Shen Z. Identification_x000D_ and subcellular localisation of hexokinase-2 in Nosema bombycis. Folia Parasitol_x000D_ (Praha). 2020 Sep 21;67:2020.023._x000D_ _x000D_ 7: Li J, Chen G, Zhang J, Shen H, Kang J, Feng P, Xie Q, Hu Z. Suppression of a_x000D_ hexokinase gene, SlHXK1, leads to accelerated leaf senescence and stunted plant_x000D_ growth in tomato. Plant Sci. 2020 Sep;298:110544._x000D_ _x000D_ 8: Aljamal JA, Badawneh M. In vitro inhibition of human erythrocyte hexokinase_x000D_ by various hyperglycemic drugs. J Biochem Mol Toxicol. 2017 Aug;31(8)._x000D_ _x000D_ 9: Krasnov GS, Dmitriev AA, Lakunina VA, Kirpiy AA, Kudryavtseva AV. Targeting_x000D_ VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer_x000D_ therapy. Expert Opin Ther Targets. 2013 Oct;17(10):1221-33._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31295070/">10: Hingst JR, Bjerre RD, Wojtaszewski JFP, Jensen J. Rapid radiochemical filter_x000D_ paper assay for determination of hexokinase activity and affinity for_x000D_ glucose-6-phosphate. J Appl Physiol (1985). 2019 Sep 1;127(3):661-667. </a>_x000D_ _x000D_ <strong>Products Related to Hexokinase from Saccharomyces cerevisiae </strong> <a href="https://moleculardepot.com/product-category/Enzymes/">: Enzymes</a>