Aminooxyacetic acid (hemihydrochloride)
Product Specifications
UNSPSC Description
Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
Target Antigen
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Aminooxyacetic_acid_hemihydrochloride.html
Purity
98.00
Solubility
DMSO : 125 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
OC(CON)=O.[H]Cl.[1/2]
Molecular Weight
109.30
References & Citations
[1]Wang C, et al. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer Lett. 2016 Aug 1;378(1):1-7.|[2]Pagliusi SR, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322(3):210-5.|[3]Korangath P, et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate. Clin Cancer Res. 2015 Jul 15;21(14):3263-73.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107994/Aminooxyacetic-acid-hemihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107994/Aminooxyacetic-acid-hemihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2921-14-4
Available Sizes
Curated Selection
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