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Aminooxyacetic acid (hemihydrochloride)

Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.

Product Specifications

CAS Number

[2921-14-4]

Product Name Alternative

Carboxymethoxylamine (hemihydrochloride) ; Aminooxyacetate (hemihydrochloride)

UNSPSC

12352211

Hazard Statement

H315, H319

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Aminooxyacetic_acid_hemihydrochloride.html

Purity

98.00

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC(CON)=O.[H]Cl.[1/2]

Molecular Formula

C2H5NO3.1/2HCl

Molecular Weight

109.30

Precautions

H315, H319

References & Citations

[1]Wang C, et al. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer Lett. 2016 Aug 1;378 (1) :1-7.|[2]Pagliusi SR, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322 (3) :210-5.|[3]Korangath P, et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate. Clin Cancer Res. 2015 Jul 15;21 (14) :3263-73.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Am J Transl Res. 2018 Dec 15;10 (12) :4247-4257.|ASN Neuro. 2021 Jan-Dec:13:17590914211043087.|Biomed Pharmacother. 2023 Nov:167:115605.|bioRxiv. 2025 July 11.|Cancer Res. 2022 Sep 16;82 (18) :3223-3235.|Cell Death Discov. 2025 Oct 6;11 (1) :430.|Cell Mol Life Sci. 2024 May 3;81 (1) :204.|CNS Neurosci Ther. 2023 Mar;29 (3) :941-956.|Comput Biol Med. 2023 Oct:165:107415.|J Virol. 2025 Nov 25;99 (11) :e0098525.|Mol Nutr Food Res. 2023 Nov;67 (22) :e2300112.|Nat Metab. 2022 Feb;4 (2) :239-253.|Phytomedicine. 2025 Nov 25:148:157492.|Redox Biol. 2024 May:71:103112.|Research (Wash D C) . 2025 May 23:8:0703.|Sci Adv. 2025 Aug 15;11 (33) :eadw9241.|Sci Adv. 2025 Aug 29;11 (35) :eadu6271.|Signal Transduct Target Ther. 2023 Feb 15;8 (1) :65.|Theranostics. 2021 Mar 24;11 (12) :5650-5674.|Viruses. 2024 Sep 29;16 (10) :1540.|Stem Cell Res Ther. 2025 Oct 31;16 (1) :603.

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