CEP1347-VHL-02
CEP1347-VHL-02 is a PROTAC targeting MLK3. CEP1347-VHL-02 consists of PROTAC target protein ligand CEP-1347 (red part), E3 ubiquitin ligase ligand (S, R, S) -AHPC-Me (HY-112078) (blue part) and PROTAC Linker Amino-PEG3-CH2COOH (HY-140189) (black part), of which the target protein ligand activity control is CEP-1347-acid (HY-168027), and the conjugate of E3 ubiquitin ligase ligand + Linker is (S, R, S) -AHPC-Me-CO-CH2-PEG3-NH2 (HY-131387).
Product Specifications
UNSPSC
12352005
Target
Mixed Lineage Kinase; PROTACs
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cep1347-vhl-02.html
Smiles
O=C([C@@]1(O)C[C@]2([H])N3C4=CC=C(CSCC)C=C4C5=C3C6=C(C7=CC(CSCC)=CC=C7N6[C@@]1(C)O2)C(CN8)=C5C8=O)NCCOCCOCCOCC(N[C@H](C(N9[C@H](C(N[C@H](C%10=CC=C(C%11=C(C)N=CS%11)C=C%10)C)=O)C[C@@H](O)C9)=O)C(C)(C)C)=O
Molecular Formula
C63H76N8O11S3
Molecular Weight
1217.52
References & Citations
[1]Karpińska K, et al. Selective Degradation of MLK3 by a Novel CEP1347-VHL-02 PROTAC Compound Limits the Oncogenic Potential of TNBC. J Med Chem. 2024 Sep 12;67 (17) :15012-15028.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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