SOCE inhibitor 1
SOCE inhibitor 1 (Compound 39) is a store-operated calcium entry (SOCE) inhibitor with an IC50 of 4.4 μM. SOCE inhibitor 1 has a good stability in plasma[1].
Product Specifications
CAS Number
[2169316-15-6]
UNSPSC
12352005
Target
CRAC Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SOCE_inhibitor_1.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C(F)(F)F)N(C2=CC=C(N3N=NC(C4=CC=CC(C(O)=O)=C4)=C3)C=C2)N=C1)OC(C)CCC
Molecular Formula
C25H22F3N5O4
Molecular Weight
513.47
References & Citations
[1]Riva B, et al. Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis. J Med Chem. 2018 Nov 8;61 (21) :9756-9783.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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