Leonurine (hydrochloride)

Leonurine hydrochloride is an alkaloid isolated from Leonurus artemisia, with anti-oxidative and anti-inflammatory.

Product Specifications

CAS Number

[24735-18-0]

Product Name Alternative

SCM-198 hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Autophagy; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Leonurine-hydrochloride.html

Purity

99.43

Solubility

DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic)

Smiles

O=C(OCCCCNC(N)=N)C1=CC(OC)=C(O)C(OC)=C1.[H]Cl

Molecular Formula

C14H22ClN3O5

Molecular Weight

347.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Jiang T, et al. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner. Cell Physiol Biochem. 2017;43 (4) :1703-1717.|[2]Zhang L, et al. Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway. Biomed Pharmacother. 2018 Dec 7;110:571-581.|[3]Hu ZC, et al. Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. J Cell Physiol. 2018 Nov 11.