FAPy-adenine
FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].
Product Specifications
CAS Number
[5122-36-1]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fapy-adenine.html
Purity
99.86
Solubility
DMSO : 17.86 mg/mL (ultrasonic)
Smiles
O=CNC1=C(N)N=CN=C1N
Molecular Formula
C5H7N5O
Molecular Weight
153.15
Precautions
H315, H319, H320
References & Citations
[1]Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease.|[2]Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54 (3-4) :239-45.|[3]Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18 (9) :973-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
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