FAPy-adenine

FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].

Product Specifications

CAS Number

[5122-36-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fapy-adenine.html

Purity

99.86

Solubility

DMSO : 17.86 mg/mL (ultrasonic)

Smiles

O=CNC1=C(N)N=CN=C1N

Molecular Formula

C5H7N5O

Molecular Weight

153.15

Precautions

H315, H319, H320

References & Citations

[1]Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease.|[2]Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54 (3-4) :239-45.|[3]Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18 (9) :973-7.