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SMS1-IN-1

SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1].

Product Specifications

CAS Number

1807943-38-9

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sms1-in-1.html

Purity

99.44

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=C(Br)C=C1)COC2=CC=C(S(=O)(NCCC3=CC=CC=C3)=O)C=C2

Molecular Formula

C23H23BrN2O4S

Molecular Weight

503.41

References & Citations

[1]Li YL, et al. Discovery, synthesis and biological evaluation of 2- (4- (N-phenethylsulfamoyl) phenoxy) acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors.Bioorg Med Chem. 2015 Sep 15;23 (18) :6173-84.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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