SMS1-IN-1
SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1].
Product Specifications
CAS Number
[1807943-38-9]
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sms1-in-1.html
Purity
99.44
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(Br)C=C1)COC2=CC=C(S(=O)(NCCC3=CC=CC=C3)=O)C=C2
Molecular Formula
C23H23BrN2O4S
Molecular Weight
503.41
References & Citations
[1]Li YL, et al. Discovery, synthesis and biological evaluation of 2- (4- (N-phenethylsulfamoyl) phenoxy) acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors.Bioorg Med Chem. 2015 Sep 15;23 (18) :6173-84.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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