Azadirachtin B

Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA) . Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties[1][2][3].

Product Specifications

CAS Number

[106500-25-8]

UNSPSC

12352005

Target

EBV; Influenza Virus; Parasite; Phosphatase

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/azadirachtin-b.html

Purity

99.17

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]1([C@@]([C@H]2C(OC)=O)([H])[C@]([C@H](C[C@H]3OC(/C(C)=C/C)=O)O)(CO2)[C@@]4([H])[C@](OC[C@@]43C(OC)=O)([H])[C@H]1O)[C@]([C@@H](O[C@]5([H])OC=C6)C[C@H]7[C@]56O)(O8)[C@]78C

Molecular Formula

C33H42O14

Molecular Weight

662.68

References & Citations

[1]Kushwaha P, et al. Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo. Bioorg Med Chem Lett. 2016 Aug 1;26 (15) :3719-24.|[2]Kanokmedhakul S, et al. Azadirachtin derivatives from seed kernels of Azadirachta excelsa. J Nat Prod. 2005 Jul;68 (7) :1047-50.|[3]Akihisa T, et al. Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indicia A. Juss. (neem) . J Oleo Sci. 2009;58 (11) :581-94.