EPZ031686
EPZ031686 is an potent and orally active SMYD3 inhibitor and with an IC50 value of 3 nM. EPZ031686 can be used for cancer research[1].
Product Specifications
CAS Number
[2095161-11-6]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EPZ031686.html
Purity
99.82
Solubility
DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1)NC2=C1C=C(C(N[C@@H]3C[C@H]4N(S(CC5CCN(CCCC(F)(F)F)CC5)(=O)=O)[C@H](CC4)C3)=O)C(Cl)=C2
Molecular Formula
C26H34ClF3N4O4S
Molecular Weight
591.09
References & Citations
[1]Mitchell LH, et, al. Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. ACS Med Chem Lett. 2015 Aug 27;7 (2) :134-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SMYD3
Available Sizes
Curated Selection
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