Mc-Val-Cit-PAB-Cl
Product Specifications
UNSPSC Description
Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).
Target Antigen
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-val-cit-pab-cl.html
Purity
99.67
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CCl)C=C2)=O)=O)=O)C=CC1=O
Molecular Weight
591.10
References & Citations
[1]Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112099/Mc-Val-Cit-PAB-Cl-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112099/Mc-Val-Cit-PAB-Cl-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1639351-92-0
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7179587 Inquire
Rabbit anti-Saccharomyces cerevisiae (strain Lalvin EC1118/Prise de mousse)(Baker's yeast) KXD1 Polyclonal Antibody
Ask
View Details 