Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Lei-Dab7 (TFA)

Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM) . Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

Product Specifications

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lei-dab7-tfa.html

Purity

99.75

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]2([H])C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@](C(N[C@@](C(NCC(NC(C(NC(C(N[C@@](C(N[C@H](C(N[C@@H](CSSC2)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC3=CN=CN3)=O)=O)=O)=O)CCC(O)=O)=O)([H])CSSC1)=O)CCCCN)=O)CC(O)=O)=O)=O)([H])[C@@H](C)CC)=O)([H])CSSC4)=O)CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)=O)CCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(N)=O)[C@H]4NC([C@@H](NC([C@@H](N)C)=O)CC5=CC=CC=C5)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C141H236N46O39S6.xC2HF3O2

Molecular Weight

3392.06 (free base)

References & Citations

[1]Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

NCX1 (SLC8A1) Rabbit Monoclonal Antibody
TA423556 100 µL

NCX1 (SLC8A1) Rabbit Monoclonal Antibody

Sign In for Pricing
View Details
Topterone
TRC-T450150-5MG 5 mg

Topterone

Sign In for Pricing
View Details
PE Anti-Mouse CD150/SLAM Antibody[TC15-12F12.2]
E-AB-F1177UD-01 25 µg

PE Anti-Mouse CD150/SLAM Antibody[TC15-12F12.2]

Sign In for Pricing
View Details
PE Anti-Mouse CD150/SLAM Antibody[TC15-12F12.2]
E-AB-F1177UD-02 100 µg

PE Anti-Mouse CD150/SLAM Antibody[TC15-12F12.2]

Sign In for Pricing
View Details
CHML Antibody
8C18118-AAT 50 µg

CHML Antibody

Sign In for Pricing
View Details
CENPA (NM_001809) Human Recombinant Protein
TP324761M 100 µg

CENPA (NM_001809) Human Recombinant Protein

Sign In for Pricing
View Details